So, what exactly are AAVs? Adeno-associated viruses (AAVs) were first identified in 1965 by Bob Atchison and Wallace Rowe, who observed them as replication-defective particles
Find out strategies such as genetic engineering and modification of MSCs to enhance safety and efficacy of MSCs in cancer therapy.
Summary The field of cancer therapy is undergoing transformative changes, driven by the following trends: iPSC-derived MSCs, MSCs-derived EVs, and Cas9-mediated gene editing in MSCs.
Yamanaka successfully produced embryonic stem cell-like cells in 2006 by introducing Oct3/4, Sox2, c-Myc, and KLF4 into somatic cells. He gave these cells the term
Wu Q, Liang X, Wang K, et al. Intestinal hypoxia-inducible factor 2α regulates lactate levels to shape the gut microbiome and alter thermogenesis. Cell Metab. 2021;33(10):1988-2003.e7. doi:10.1016/j.cmet.2021.07.007
Li, Y., Lu, Y., Lin, SH. et al. Insulin signaling establishes a developmental trajectory of adipose regulatory T cells. Nat Immunol 22, 1175–1185 (2021). https://doi.org/10.1038/s41590-021-01010-3
Mice are commonly used as a mammalian model for studying of human diseases. They are small, cost-effective, reproduce quickly and easy to handle. They are
Preclinical Animal Models for CAR-T Cell Therapy Chimeric antigen receptor (CAR)-T cell therapy is one of the leading immunotherapies in oncology. Although many clinical trials
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