GemPharmatech has focused on generating mouse models for four types of spontaneous tumors that are frequently identified in human patients: pancreatic cancer, hepatobiliary cancer, breast cancer and colorectal carcinoma. Find the Spontaneous tumor mouse models you need below.

Tumors are excessive accumulation of bodily mass, including solid tissue and fluid.

Cancer is the overgrowth of solid mass, which can be benign or malignant. With the advance of cancer biology, our understanding of the driving forces of tumorigenesis has increased substantially. Accumulating evidence suggests that many types of tumors are results of spontaneous mutations in genes or the genome.

Many of such mutations are somatic and not passed from the affected individual to his or her offspring.

Through GWAS analyses, genes and genetic hot spots for mutagenesis have been identified. For example, in a 2017 study, 93% and 72% of pancreatic cancer patients are found to have acquired spontaneous mutations in KRAS and TRP53, respectively.

Despite gender difference in cancer occurrences, two out of the top four most frequently diagnosed cancer types are the same in males and females: lung & bronchus and colon & rectum are #2 and #3, while prostate and breast cancers are #1 for men and women, respectively.

Given the genetic similarities between humans and mice, murine strains carrying genetic mutations mimicking human disease genes have proven to be a valuable tool for studying disease mechanism and the development of therapeutic interventions.