The type II collagen-induced arthritis (CIA) mouse model is the most widely used model to study rheumatoid arthritis (RA). CIA model can be used for preclinical studies and efficacy evaluation of RA therapeutics.

Modeling strategy

Validation data

  1. Phenotypic data of CIA model (DBA1/J)

An adjuvant containing bovine collagen type II was injected subcutaneously into the tail of mice. The forelimbs, hindlimbs and paws of the mice were observed and scored weekly. The score of the arthritis group was significantly higher than that of the control group. 10 weeks after the first immunization, the paw of the hind limb showed obvious swelling in the CIA mice (yellow arrowheads).

  2. Efficacy Results of anti-IL17A drugs in CIA Models (DBA-hIL17A)

DBA-hIL17A mice were used for CIA, and administered with Cosentyx (Secukinumab) and test drug X (targeting hIL17A). The results showed that the two drugs had therapeutic effects on DBA-hIL17A arthritis mice.