Recombinant Human Tumor Necrosis Factor-alpha (rHu TNF-a) is secreted by macrophages, monocytes, neutrophils, T-cells, NK-cells following their stimulation by bacterial LPS.

TNF-α causes cytolysis and cytostasis of many tumor cell lines in vitro. It also enhances phagocytosis and cytotoxicity in neutrophilic granulocytes and modulates the expression of many other proteins. Cells expressing CD4 secrete TNF-α while CD8 cells secrete little or no TNF-alpha. rHu TNF-α, produced in E. coli is a single, non-glycosylated, polypeptide chain that contains 158 amino acids and has a molecular mass of 17.48 kDa.

Features and Specifications:

• Custom packaging and sizes available
• Single-use syringe configuration
• Lyophilized or liquid format
• Pharmaceutical grade
• Sterile-filled
• Custom biological activity assays available

Quality Statement

Akron’s cGMP Cytokines are manufactured, tested and released in compliance with relevant cGMP guidelines. USP Chapter ‹1043› “Ancillary materials for cell, gene and tissue-engineered products” has been followed in the design of these products.