PhenoDrive is a class of synthetic biomaterials which are able to:

Characteristics

• Mimic the components of the extracellular matrix of a range of tissues
• Promote cellular architecture to regulate cell phenotype, promote cell function and maintain viability
• Coat all types of tissue culture plastic, glassware and porous 3D scaffolds
• Support cell construct formation in suspension

Features

• Provided to you as an easy to reconstitute powder
• Coats your plastic-wear and scaffolds in one simple step
• Controls the phenotype of your cells
• Acts as a biomimetic additive for bioink for 3D printing

Application

• Coating for plastics in traditional 2D culture or the decoration of 3D scaffolds and incorporation into bioinks
• Promote the expansion, differentiation, and control of cells of mammalian origin
• Suitable various of cell types

Publications

• Perugini V, Santin M. A comparative in vitro study of the effect of biospecific integrin recognition processes and substrate nanostructure on stem cell 3D spheroid formation. J Mater Sci Mater Med. 2020;31(4):37. Published 2020 Mar 23. doi:10.1007/s10856-020-06373-x
• Kim JJ, Bax DV, Murphy R, Best SM, Cameron RE. Collagen Film Activation with Nanoscale IKVAV-Capped Dendrimers for Selective Neural Cell Response. Nanomaterials (Basel). 2021;11(5):1157. Published 2021 Apr 28. doi:10.3390/nano11051157
• Perugini V, Flaherty SM, Santin M. Development of scaffold-free vascularized pancreatic beta-islets in vitro models by the anchoring of cell lines to a bioligand-functionalized gelatine substrate. J Mater Sci Mater Med. 2022;33(4):37. Published 2022 Apr 11. doi:10.1007/s10856-022-06658-3
• Perugini V, Santin M. A Substrate-Mimicking Basement Membrane Drives the Organization of Human Mesenchymal Stromal Cells and Endothelial Cells Into Perivascular Niche-Like Structures. Front Cell Dev Biol. 2021;9:701842. Published 2021 Sep 28. doi:10.3389/fcell.2021.701842