OMEGA4-2mini
Neuronal Co-Culture Device

This microfluidic co-culture device for neurons has been specifically designed to reduce the culture size on one side of the experimental unit, ideal for expensive cell lines! Each experimental unit consists of one standard sized chamber and one small chamber.

OMEGA^4-2mini devices can be used for in vitro co-culture studies of neurodegeneration, neuromuscular junction (NMJ), nigrostriatal pathway, pain, myelination, or chemotactic factors. In single culture applications, the OMEGA^4-2mini can serve as a  compartmentalization tool to separate the somatic and axonal components of neurons.

OMEGA^4-2mini device features:

• Experimental unit: one standard sized chamber and one small chamber
• Ready to use: sterile, hydrophilic, and pre-bonded to a high-transmissive glass coverslip
• Two experiments can be performed per device – double your data!
• Open-chamber design provides full access to your cultures – room to use explants or  self-assembled 3D cultures (organoids) in your experiments!
• Choose between Starter Kit and Refill Kit

Would you rather have identical culture chambers on either side of the microchannels? Then the OMEGA⁴ might be right for you.

Description

OMEGA^4-2mini devices are suited for in vitro co-culture studies involving:

• Neuromuscular junction (NMJ) in the context of ALS, Kennedy’s disease (SBMA), Duchenne’s muscular dystrophy
  • e.g. motor neuron/muscle co-culture

• Nigrostriatal pathway in the context of Parkinson’s disease
  • e.g. dopaminergic neuron (SNc)/GABAergic neuron (striatal) co-culture

• Sensory system in the context of nociception and mechanosensation
  • e.g. skin fibroblast/DRG co-culture

• Myelination
  • e.g. neuron/oligodendrocyte or Schwann cell co-culture

• Enteric nervous system
  • e.g. enteroendocrine cells/vagal neuron co-culture

Culture compatibility:

• iPSC-derived cultures
• Self-assembled 3D cultures (e.g. spheroids, organoids)
• Primary cultures
• Tissue explants
• Immortalized Cell lines

OMEGA^4-2mini specifications:

• Glass coverslip: 22 mm, round, #1.5 thickness
• Chamber #1 surface area: ~0.35 cm²
• Chamber #2 surface area: ~0.175 cm²
• Number of microchannels per interface: 70
• Microchannel length: ~640 µm

The OMEGA^4-2mini Starter Kit includes:

• 4 x OMEGA^4-2mini devices (each containing 2 interfaces)
• 4 x evaporation minimizing culture inserts (for 35 mm dishes)
• 4 x sterile culture dishes (35 mm, round)
• 1 x microscopy adapter for OMEGA series devices

The OMEGA^4-2mini Refill Kit includes:

• 4 x OMEGA^4-2mini devices (each containing 2 interfaces)
• 4 x sterile culture dishes (35 mm, round)

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