Obesity Mouse Models
Obesity Mouse Models
Add to cart
Obesity is a metabolic disorder that can be caused by numerous factors such as diet, environment, lifestyle and genetics.
In addition to weight gain, it can lead to a series of complications, including diabetes, hypertension, hyperlipidemia, and heart disease.
For the in-depth study of the pathogenesis of obesity and the evaluation of relevant therapeutics, GemPharmatech has developed a series of obesity mouse models, including diet-induced obesity models, genetic mutation-induced spontaneous obesity models, chromosomal substitution-based obesity model.
|
Strain No.
|
Strain Name | Strain Type | Description |
|---|---|---|---|
| T017633 | B6-Alms1-del(c.3802-3812) | Cas9-KO(TM) | An 11-bp base deletion in exon 8 of the Alms1 gene in C57BL/6JGpt mice led to early termination of translation of the Alms1 gene, leading to a combined phenotype of obesity, early diabetes and non-alcoholic fatty liver disease. These mice are ideal models for studies on obesity and fatty liver. |
| T002040 | C57BL/6JGpt DIO 60%(Diet Induced Obesity) | Diet-induced | Moderate obesity and mild insulin resistance are induced with a 60% high-fat diet in C57BL/6JGpt mice. These mice are applicable to studies on obesity and obesity-related complications. |
| D000750 | B6-Chr1 YP1 (Wild Mouse) | Chromosome Segment Substitution Lines (CSSL) | After 8 weeks of age, D000750 mice develop spontaneous obesity with significantly elevated cholesterol levels and mildly elevated blood glucose levels. These mice can develop a fatty liver phenotype with age and are applicable to studies on fatty liver disease, hyperlipidemia, cardiovascular disease, and obesity. Western diet (WD) induction accelerates the appearance of NASH symptoms. |
| T001461 | B6-ob | Cas9-KO | In C57BL/6JGpt mice, knocking out the Leptin gene causes severe morbid obesity, temporary blood glucose elevation, compensatory expansion of the islets of the Langerhans, and severe insulin resistance, with mild complications. |
Related Products
HOW CAN WE HELP YOU? Our specialists are to help you find the best product for your application. We will be happy to help you find the right product for the job.
TALK TO A SPECIALIST
Contact our Customer Care, Sales & Scientific Assistance
EMAIL US
Consult and asked questions about our products & services
DOCUMENTATION
Documentation of Technical & Safety Data Sheet, Guides and more..
NEWSLETTER
We gladly support you by keeping you updated on our latest products and the developments around our services.
ATLANTIS BIOSCIENCE PTE LTD
362 Upper Paya Lebar Rd, #07-15,
Singapore 534963
WeChat ID: +65 8608 0974
© 2015-2023 Atlantis Bioscience Pte Ltd. All rights reserved. Co Reg No: 201539516N