Human Immune System Reconstituted NCG

Animal Models (Preclinical), Categories, Disease Mouse Models, Drug Discovery & Development, Immuno-Oncology Mouse Models, Preclinical Research, Research Fields

Human Immune System Reconstituted NCG

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Categories: Animal Models (Preclinical)Categories Disease Mouse Models Drug Discovery & Development Immuno-Oncology Mouse Models Preclinical Research Research Fields

Description

There is a growing demand for specialised mouse models with human immune systems for drug development in cancer, infectious and autoimmune diseases. Immunodeficient mice are often used for this purpose, as they have shown to engraft human cells and tissues more efficiently than other models.
Our models utilise the NCG immunodeficient mouse model that lacks the mouse’s natural immune system to create an environment with human immune cells.

Comparison of huPBMC-NCG and huHSC-NCG mice

	huPBMC-NCG mice	huHSC (CD34+)-NCG mice
Irradiation	No	Yes
GvHD	High	Low
Reconstruction period	2 weeks	8-10 weeks
Human immune cells	T cells	T cells, B cells, NK cells, Myeloid cells
Available time	4-5 weeks	> 18 weeks
Summary	Ideal model for short-term study	Ideal model for long-term study