Product Description

CRISPR/Cas9-rAAV Vectors – Genome Editing Research

Our pre-made CRISPR/Cas9 AAV vectors provide a powerful and efficient tool for precise genome editing. Designed to streamline your research workflow, these vectors offer a range of features to meet your specific needs.

Key Features:

High-Efficiency Cas9 Expression: Our vectors deliver robust Cas9 expression, ensuring efficient gene editing.

Versatile Serotypes: Choose from a variety of serotypes to target specific tissues and cell types.

Flexible Promoters: Select from a range of promoters to control gene expression levels.

Rapid Turnaround: Our pre-made vectors are available for immediate shipping, accelerating your research timeline.

High–Quality Production: Rigorously tested and quality-controlled to ensure optimal performance.

Applications:

• Gene Knockout: Precisely disrupt gene function to study gene loss-of-function phenotypes.
• Gene Knock-In: Introduce specific genetic modifications, such as point mutations or insertions.
• Gene Activation and Repression: Modulate gene expression levels using CRISPR-based transcriptional activators and repressors.
• Genome Engineering: Create complex genetic modifications, including large deletions, inversions, and translocations.

Simplify Your Workflow, Maximize Your Impact

Our pre-made CRISPR/Cas9 AAV vectors are designed to simplify your genome editing experiments. By eliminating the need for time-consuming vector construction and production, you can focus on your core research objectives.

Contact us today to discuss your research goals and explore our range of pre-made and custom CRISPR/Cas9 AAV vectors.

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Product Specification

Case Study

Products: CRISPR AAV vectors from PackGene Biotech
Injection Method: Intramuscular Injection
Recommended Dose: 25 μL, 1.5E+12 vg/ml
Targeting Site: muscle
Animal Model: DMD mouse model
Journal: Genome Medicine, 2021 (IF=15.266)
Paper Title: In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers
DOI: 10.1186/s13073-021-00876-0

AAV production and injection
CRISPR AAV vectors were generated by PackGene Biotech Co. For intramuscular injection into NSI mice, the animals were anesthetized by abdominal injection of 5% chloral hydrate, followed by
injection of CRISPR AAV vector (25 μL, 1.5E+12 vg) into the TA muscle transplanted with DMD–MDSCs.