Circulating tumour Cells (CTC)

• Liquid Biopsy – detecting cancers through a simple blood draw
• CTC is rare (1 in 109 cells) – detecting CTCs with high sensitivity and specificity is a major challenge

GMP production

1.  2 paper citations by CellSearch Inventor (Professor Leon Terstappen)
2. Clinical data in breast, colorectal, gastric, head & neck, non-small cell lung cancers

• —  Most sensitive platform with high specificity – EpCAM antibody with the highest binding affinity (Kd < 10-12)
• —  2 paper citations by CellSearch Inventor (Professor Leon Terstappen)
• —  Detecting CTCs in >95% of patients enrolled (n > 125)
• —  Capturing live CTCs for culturing (success rate reaching ~96%, n = 50)
• —  Successfully performed NGS on CTCs captured from patients
• —  Can capture CTC with low EpCAM Expressions (e.g., CTCs with EMT, MDA-MB-231)

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