Alginate Beads Generation
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Elveflow’s Easy Droplet Generation Pack contains one pumping channel to flow the aqueous alginate phase and another pumping channel to push the continous oil phase and another pumping channel to push the continous oil phase through our droplet generation chip, enabling the generation of alginate droplets in oil. The droplet size is determined by the chip channel size and flow rate ratio of both phases.
Based on our high accuracy OB1 flow controllers, this all-in-one solution contains all the required parts for researchers to set up their own alginate beads generation system out of the box. It brings the many benefits of microfluidics, including excellent monodispersity, sphericality, reproducibility, and high throughput compared to other hydrogel particle production techniques.
EASY MICRON SIZE BEADS GENERATION
⇒Unbox, set up and start your experiments using our application note
REPRODUCIBLE & HIGH MONODISPERSITY
⇒Produce monodisperse hydrogel beads (PDI <5%)
PERFECT FOR MANY APPLICATIONS
⇒Including drug delivery, wound healing, cell & tissue culture
Highlights
A standard alginate beads generation pack contains one pumping channel to flow the aqueous alginate phase and another pumping channel to push the continuous oil phase through our droplet generation chip, enabling the generation of alginate droplets in oil.
The droplet size will be determined by the chip channel size and the flow rate ratio of both phases. Flow rates can be measured thanks to our multiple flow rate sensors (MFS or BFS series).
For the detailed experimental steps, please refer to our application note!
Applications
Reviews
- Microfluidics for PLGA nanoparticles synthesis: a review
- Confined particles in microfluidic devices: a review
- Sodium Alginate and applications: a review
- Introduction to droplet-based microfluidics
- Microfluidic magnetic particle sorting and separation : a short review
- Microfluidics as a tool for drug delivery
- Microfluidic Nanoparticle Synthesis: A short review
Publications
3D flow-focusing microfluidic biofabrication: One-chip-fits-all hydrogel fiber architectures, Rui L. Reis et al. , Applied Materials Today (2021).
Additive batch electrospinning patterning of tethered gelatin hydrogel fibres with swelling-induced fibre curling
Elisabeth L. Gill, Wenyu Wang, Ruishan Liu, Yan Yan Shery Huang, Additive Manufacturing, 2020, Volume 36, 101456, DOI: 10.1016/j.addma.2020.101456
Highly Ordered Gelatin Methacryloyl Hydrogel Foams with Tunable Pore Size
Friederike Dehli, Lisa Rebers, Cosima Stubenrauch, and Alexander Southan, Biomacromolecules 2019 20 (7), 2666-2674 DOI: 10.1021/acs.biomac.9b00433
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Specifications
The amazing benefits of microfluidics can be applied to many droplet applications and therefore the content of the alginate pack can be adjusted to suit your specific needs. Contact us for more details.
CONTENT
- OB1 FLOW CONTROLLERÂ with at least two channels 0/2000 mbar
- 2x flow sensors MFS2 0/7 µL/min (see also the Coriolis flow sensor for the best performance)
- Kit starter pack Luer Lock + 1/32 tubings + 1/32 sleeves + 23G needles
- 2x 15 mLÂ Falcon
- Microfluidic chip (hydrophobic channels)
- 1 x vial of droplet oil
- control and automation software
- User guide which includes a beads size diagram, allowing you to pick up the right flow rates to achieve a desired bead size
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