APC Anti-Human CD23 (EBVCS-5)
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The EBVCS-5 antibody is specific for human CD23, also known as the low affinity IgE receptor (FceRII), a 45 kDa type II transmembrane protein and member of the immunoglobulin superfamily. It is expressed on most B cells and is upregulated upon activation. It is also present on mantle zone B cells, eosinophils, monocytes and a subset of T cells and platelets. CD23 plays a role in B cell development and differentiation, and also functions to regulate IgE production. Soluble secreted forms of CD23 have been reported to bind IgE, stimulate release of pro-inflammatory cytokines from monocytes, and play a role in B cell differentiation.
Product Details
| Name | APC Anti-Human CD23 (EBVCS-5) |
|---|---|
| Cat. No. | 20-0237 |
| Alternative Names | FcER2, Fc?RII, Low affinity immunoglobulin epsilon Fc receptor, BLAST-2, Leu-20, B6 |
| Gene ID | 2208 |
| Clone | EBVCS-5 |
| Isotype | Mouse IgG1, kappa |
| Reactivity | Human |
| Cross Reactivity | |
| Format | APC |
| Application | Flow Cytometry |
| Citations* | Knapp W, Dorken B, et al. eds. 1989. Leucocyte Typing IV: White Cell Differentiation Antigens. Oxford University Press. New York.
Yukawa K, Kikutani H, Owaki H, Yamasaki K, Yokota A, Nakamura H, Barsumian EL, Hardy RR, Suemura M and Kishimoto T. 1987. J Immunol. 138(8): 2576-2580. Armant M, Ishihara H, Rubio M, Delespesse G and Sarfati M. 1994. J Exp Med. 1994. 180(3): 1005-1011. Belleau JT, Gandhi RK, McPherson HM and Lew DB. 2005. Clin Mol Allergy. 3:6. (Flow cytometry) Farren TW, Giustiniani J, Liu FT, Tsitsikas DA, Macey MG, Cavenagh JD, Oakervee HE, Taussig D, Newland AC, Calaminici M, Bensussan A, Jenner M, Gribben JB and Agrawal SG. 2011. Blood. 118(8): 2174-2183. (Flow cytometry) Cromvik J, Johnsson M, Vaht K, Johansson JE and Wenneras C. 2014. Immun Inflamm Dis. 2(2): 99-113. (Flow cytometry) |
Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy
*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.
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