In Vivo Ready™ Anti-Human CD28 (CD28.6) – 100 µg

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Product Description

The CD28.6 antibody reacts with human CD28, a 44 kDa type I surface glycoprotein which acts as a co-stimulatory receptor in support of the T cell receptor (TCR). CD28 exists as a homodimer with specificity for two known ligands, known as B7-1 (CD80) and B7-2 (CD86), which are expressed on activated B cells and antigen-presenting cells. These ligands trigger CD28 signaling in concert with TCR activation to drive T cell proliferation, induce high-level expression of IL-2, impart resistance to apoptosis, and enhance T cell cytotoxicity. The interaction / co-stimulatory signaling between ≥ ≥ ≥ the B7 ligands and CD28 provides crucial communication between ≥ ≥ ≥ T cells and B cells or APCs to coordinate the adaptive immune response. The CD28.6 antibody is reported to have neutralizing activity and is also useful for western blotting.

Product Details

Name	In Vivo Ready™ Anti-Human CD28 (CD28.6)
Cat. No.	40-0288
Alternative Names	T44
Gene ID	940
Clone	CD28.6
Isotype	Mouse IgG2a, κ
Reactivity	Human
Cross Reactivity	Human
Format	FITC
Application	Flow Cytometry, Functional Assays, Western Blot
Citations*	Yang JH, Zhang J, Cai Q Yang JH, Zhang J, Cai Q, Zhao DB, Wang J, Guo PE, Liu L, Han XH, Shen Q. 2005. Rheumatology (Oxford). Oct;44(10):1245-1254. Zhang XG, Olive D, Devos J, Rebouissou C, Ghiotto-Ragueneau M, Ferlin M, Klein B. 1998. Leukemia. Apr;12(4):610-618. Kariv I, Truneh A, Sweet RW. 1996. J Immunol. Jul 1;157(1):29-38. Nunes J, Klasen S, Ragueneau M, Pavon C, Couez D, Mawas C, Bagnasco M, Olive D. 1993. Int Immunol. Mar;5(3):311-315.

Application Key:FC = Flow Cytometry; FA = Functional Assays; ELISA = Enzyme-Linked Immunosorbent Assay; ICC = Immunocytochemistry; IF = Immunofluorescence Microscopy; IHC = Immunohistochemistry; IHC-F = Immunohistochemistry, Frozen Tissue; IHC-P = Immunohistochemistry, Paraffin-Embedded Tissue; IP = Immunoprecipitation; WB = Western Blot; EM = Electron Microscopy

*Tonbo Biosciences tests all antibodies by flow cytometry. Citations are provided as a resource for additional applications that have not been validated by Tonbo Biosciences. Please choose the appropriate format for each application and consult the Materials and Methods section for additional details about the use of any product in these publications.