CRISPR/Cas9-rAAV Vectors – Genome Editing Research

CRISPR/Cas9-rAAV Vectors – Genome Editing Research

CRISPR/Cas9-rAAV Vectors – Genome Editing Research

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CRISPR/Cas9-rAAV Vectors – Genome Editing Research

Our pre-made CRISPR/Cas9 AAV vectors provide a powerful and efficient tool for precise genome editing. Designed to streamline your research workflow, these vectors offer a range of features to meet your specific needs.

 

Key Features:

High-Efficiency Cas9 Expression: Our vectors deliver robust Cas9 expression, ensuring efficient gene editing.

Versatile Serotypes: Choose from a variety of serotypes to target specific tissues and cell types.

Flexible Promoters: Select from a range of promoters to control gene expression levels.

Rapid Turnaround: Our pre-made vectors are available for immediate shipping, accelerating your research timeline.

HighQuality Production: Rigorously tested and quality-controlled to ensure optimal performance.

 

Applications:

  • Gene Knockout: Precisely disrupt gene function to study gene loss-of-function phenotypes.
  • Gene Knock-In: Introduce specific genetic modifications, such as point mutations or insertions.
  • Gene Activation and Repression: Modulate gene expression levels using CRISPR-based transcriptional activators and repressors.
  • Genome Engineering: Create complex genetic modifications, including large deletions, inversions, and translocations.

 

Simplify Your Workflow, Maximize Your Impact

Our pre-made CRISPR/Cas9 AAV vectors are designed to simplify your genome editing experiments. By eliminating the need for time-consuming vector construction and production, you can focus on your core research objectives.

 

Contact us today to discuss your research goals and explore our range of pre-made and custom CRISPR/Cas9 AAV vectors.

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Product Specification

 

Promoter type Catalog No. Promoter and Gene
Universal promoter AAV-XA20 ssAAV.miniCMV.SpCas9
AAV-XA02 ssAAV.EFS.SpCas9
AAV-XB02 ssAAV.EFS.SpCas9HF
AAV-XB06 ssAAV.miniCMV.SpCas9HF
AAV-AC010 ssAAV.EFS.SaCas9
AAV-AC040 ssAAV.CMV.SaCas9
AAV-AD040 ssAAV.CMV.SaCas9HF
AAV-AD010 ssAAV.EFS.SaCas9HF
AAV-XE01G ssAAV.EFS.AsCpfl
AAV-XE01H ssAAV.EFS.LbCpfl
AAV-XE02H ssAAV.miniCMV.LbCpfl
Tissue-specific promotor AAV-AC050 ssAAV.TBG.SaCas9
AAV-AC060 ssAAV.Elastasel.SaCas9
AAV-AC070 ssAAV.Rat Insulin 2.SaCas9
AAV-AC080 ssAAV.mouse Insulin2.SaCas9
AAV-AC090 ssAAV.hDesmin.SaCas9
AAV-AC100 ssAAV.hSynapsin.SaCas9
AAV-AC120 ssAAV.pMECP2.SaCas9
AAV-AC190 ssAAV.CBh.Sacas9.WPRE.SV40pA
AAV-AC071 ssAAV.Rat Insulin 2.SaCas9.U6.(Sa)sgRNA
AAV-AC081 ssAAV.mouse Insulin2.SaCas9.U6.(Sa)sgRNA
AAV-AC091 ssAAV.hDesmin.SaCas9.U6.(Sa)sgRNA
AAV-AC101 ssAAV.hSynapsin.SaCas9.U6.(Sa)sgRNA
AAV-AC121 ssAAV.pMECP2.SaCas9.U6.(Sa)sgRNA
AAV-AD060 ssAAV.Elastasel.SaCas9HF
AAV-AD070 ssAAV.rlnsulin2.SaCas9HF
AAV-AD080 ssAAV.mlnsulin2.SaCas9HF
AAV-AD090 ssAAV.hDesmin.SaCas9HF
AAV-AD100 ssAAV.hSynapsin.SaCas9HF
AAV-AD120 ssAAV.MECP2.SaCas9HF

Case Study

Products: CRISPR AAV vectors from PackGene Biotech
Injection Method: Intramuscular Injection
Recommended Dose: 25 μL, 1.5E+12 vg/ml
Targeting Site: muscle
Animal Model: DMD mouse model
Journal: Genome Medicine, 2021 (IF=15.266)
Paper Title: In vivo genome editing in mouse restores dystrophin expression in Duchenne muscular dystrophy patient muscle fibers
DOI: 10.1186/s13073-021-00876-0

AAV production and injection
CRISPR AAV vectors were generated by PackGene Biotech Co. For intramuscular injection into NSI mice, the animals were anesthetized by abdominal injection of 5% chloral hydrate, followed by
injection of CRISPR AAV vector (25 μL, 1.5E+12 vg) into the TA muscle transplanted with DMD–MDSCs.