Non-parenchymal cells (NPCs) isolation enables the possibility to obtain liver models mimicking the microenvironment and microanatomy of the human liver for the study of liver functions. Moreover, these models present organotypic hepatocyte-NPC interactions via direct contact or paracrine signalling. Therefore, these models are able to recreate the physiological in vivo environment and this is a fundamental requirement to obtain a specific predictive response for the study of liver physiology/pathology or to perform new drug screenings and safety analysis with a high predictive value.
PRIMARY HUMAN HEPATOCYTES AVAILABLE
Kupffer Cells
Hepatic Stellate Cells
Liver Endothelial Cells
NPCs Mix
COMMON USES
– Metabolism analysis
– Drug development
– Toxicity assessments
– Enzyme activity studies
– Among others
DOCUMENTATION